Tautomeric origin of dual effects of N1-nicotinoyl-3-(4′-hydroxy- 3′-methyl phenyl)-5-[(sub)phenyl]-2-pyrazolines on bacterial and viral strains: POM analyses as new efficient bioinformatics' platform to predict and optimize bioactivity of drugs

DOI: 10.1007/s00044-012-0143-6

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Medicinal Chemistry Research p. 1438 - 1449 (2013)

Update date:2022-09-26

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Authors:

Hadda, Taibi Ben

Ali, Mohamed A.

Masand, Vijay

Gharby, Said

Fergoug, Teffaha

Warad, Ismail

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Article abstract of DOI:10.1007/s00044-012-0143-6

In this study, we have amalgamated computational methodologies, viz. Petra, Osiris and Molinspiration (POM) to identify pharmacophores and antipharmacophores for antibacterial/antiviral activities of some 2-pyrazolines derivatives. Lipophilicity and the p

Full text of DOI:10.1007/s00044-012-0143-6

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