Synthesis and Dihydropteridine Reductase Inhibitory Effects of Potential Metabolites of the Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

DOI: 10.1021/jm00381a009

Source and publish data:

Journal of Medicinal Chemistry p. 311 - 317 (1985)

Update date:2022-09-26

Topics:

Authors:

Gessner, Wieslaw

Brossi, Arnold

Shen, Rong-sen

Abell, Creed W.

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Article abstract of DOI:10.1021/jm00381a009

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a nigrostriatal neurotoxin which can cause irreversible parkinsonism in humans and primates by selective destruction of neurons in the substantia nigra.It is possible that MPTP could be metabolized by

Full text of DOI:10.1021/jm00381a009

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