TOTAL SYNTHESIS OF (-)-SWAINSONINE, AN α-MANNOSIDASE INHIBITOR ISOLATED FROM SWAINSONA CANESCENS

DOI: 10.1246/cl.1984.513

Source and publish data:

Chemistry Letters p. 513 - 516 (1984)

Update date:2022-08-04

Topics:

Authors:

Suami, Tetsuo

Tadano, Kin-ichi

Iimura, Youichi

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Article abstract of DOI:10.1246/cl.1984.513

The alkaloidal toxin, (-)-swainsonine: (1S,2R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizine has been synthesized stereoselectively starting from methyl 3-acetamido-2,4,6-tri-O-acetyl-3-deoxy-α-D-mannopyranoside in a 15 steps rection.

Full text of DOI:10.1246/cl.1984.513

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