Bioorganic and Medicinal Chemistry Letters p. 1673 - 1676 (1999)
Update date:2022-08-05
Topics:
Van den Nieuwendijk, Adrianus M.C.H.
Benningshof, Jorg C. J.
Wegmann, Volker
Bank, Ruud A.
Te Koppele, Johan M.
Brussee, Johannes
Van der Gen, Arne
A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis.
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