Synthesis of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril).

DOI: 10.1002/jps.2600740330

Source and publish data:

Journal of Pharmaceutical Sciences p. 352 - 354 (1985)

Update date:2022-08-03

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Authors:

Douglas Douglas

Ondeyka Ondeyka

Payne Payne

Ikeler Ikeler

Joshua Joshua

Patchett

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Article abstract of DOI:10.1002/jps.2600740330

The synthesis and some of the spectral properties of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril, MK-521) are described. This compound inhibits angiotensin-converting enzyme with an IC50 of 1.2 X 10(-9) M.

Full text of DOI:10.1002/jps.2600740330

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