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Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor

DOI: 10.1016/j.bmc.2018.07.045

Source and publish data:

Bioorganic and Medicinal Chemistry p. 4650 - 4663 (2018)

Update date:2022-08-03

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Authors:

Lindemann, MarcelLindemann, Marcel

Hinz, SonjaHinz, Sonja

Deuther-Conrad, WinnieDeuther-Conrad, Winnie

Namasivayam, VigneshwaranNamasivayam, Vigneshwaran

Dukic-Stefanovic, SladjanaDukic-Stefanovic, Sladjana

Teodoro, RodrigoTeodoro, Rodrigo

Toussaint, MagaliToussaint, Magali

Kranz, MathiasKranz, Mathias

Juhl, CathleenJuhl, Cathleen

Steinbach, J?rgSteinbach, J?rg

Brust, PeterBrust, Peter

Müller, Christa E.Müller, Christa E.

Wenzel, BarbaraWenzel, Barbara

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Article abstract of DOI:10.1016/j.bmc.2018.07.045

On the basis of a pyrazine core structure, three new adenosine A2B receptor ligands (7a–c) were synthesized containing a 2-fluoropyridine moiety suitable for 18F-labeling. Compound 7a was docked into a homology model of the A2B<

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Full text of DOI:10.1016/j.bmc.2018.07.045

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