A practical enantioselective synthesis of a novel peptide deformylase inhibitor

DOI: 10.1021/op050165y

Source and publish data:

Organic Process Research and Development p. 78 - 93 (2006)

Update date:2022-08-05

Topics:

Authors:

Slade, Joel

Parker, David

Girgis, Michael

Mueller, Martin

Vivelo, James

Liu, Hui

Bajwa, Joginder

Chen, Guang-Pei

Carosi, Joseph

Lee, Paul

Chaudhary, Apurva

Wambser, Dana

Prasad, Kapa

Bracken, Kathryn

Dean, Karl

Boehnke, Helmut

Repic, Oljan

Blacklock, Thomas J.

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Article abstract of DOI:10.1021/op050165y

A practical synthesis of the peptide deformylase inhibitor LBM415,(2S)-N-(5-fluoro-1-oxido-2-pyridinyl)-1-[(2R)-2-[(formylhydroxyamino) methyl]-1-oxohexyl]-2-pyrrolidinecarboxamide, magnesium salt 11, is described. The key chiral intermediate, (2S)-N-(5-f

Full text of DOI:10.1021/op050165y

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