Synthesis of linearly and angularly fused indane-based constrained α-amino acid derivatives

Article abstract of DOI:10.1055/s-0030-1260145

The benzocyclobutene-based α-amino acid derivative, ethyl 5-acetamido-2,4,5,6-tetrahydro-1H-cyclobuta[f]indene-5-carboxylate is synthesized via coupling of a benzocyclobutene-derived dibromide with ethyl isocyanoacetate as the key step, followed by hydrolysis and subsequent acetylation. This methodology is generalized in order to prepare various linearly and angularly fused indane-based α-amino acid derivatives. Georg Thieme Verlag Stuttgart - New York.