Design and synthesis of an orally active matrix metalloproteinase inhibitor

DOI: 10.1016/j.bmc.2006.05.040

Source and publish data:

Bioorganic and Medicinal Chemistry p. 6383 - 6403 (2006)

Update date:2022-08-03

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Authors:

Yamamoto, Shingo

Nakatani, Shingo

Ikura, Masahiro

Sugiura, Tsuneyuki

Nishita, Yoshitaka

Itadani, Satoshi

Ogawa, Koji

Ohno, Hiroyuki

Takahashi, Kanji

Nakai, Hisao

Toda, Masaaki

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Article abstract of DOI:10.1016/j.bmc.2006.05.040

A series of 4-(4-phenoxy)benzoylamino-4-methoxymethyloxymethyl butyric acid hydroxamates, which were derived from l-glutamic acid, were synthesized and evaluated as matrix metalloproteinase inhibitors. Most of the compounds listed in Tables 1-3 exhibited

Full text of DOI:10.1016/j.bmc.2006.05.040

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