TRIMETHYLSILYL TRIFLUORMETHANESULFONATE (TRIMETHYLSILYL TRIFLATE) AS AN EXCELLENT GLYCOSIDATION REAGENT FOR ANTHRACYCLINE SYNTHESIS. SIMPLE AND EFFICIENT SYNTHESIS OF OPTICALLY PURE 4-DEMETHOXYDAUNORUBICIN

Article abstract of DOI:10.1246/cl.1984.501

The title reagent was found to effect the glycosidation of (+)-4-demethoxyanthracyclinones with N-trifluoracetyl-1,4-di-O-p-nitrobenzoyl-L-daunosamine, giving the α-glycosides in 99percent yields.Sequential deprotections of the glycoside readily afforded optically pure (+)-4-demethoxydaunorubicin.