Bioorganic and Medicinal Chemistry Letters p. 15 - 20 (2016)
Update date:2022-07-30
Topics:
Ma, Zhihua
Lin, Daniel C.-H.
Sharma, Rajiv
Liu, Jinqian
Zhu, Liusheng
Li, An-Rong
Kohn, Todd
Wang, Yingcai
Liu, Jiwen
Bartberger, Michael D.
Medina, Julio C.
Zhuang, Run
Li, Frank
Zhang, Jane
Luo, Jian
Wong, Simon
Tonn, George R.
Houze, Jonathan B.
As a follow-up to the GPR40 agonist AMG 837, which was evaluated in clinical trials for the treatment of type II diabetes, further optimization led to the discovery of AM-3189 (13k). AM-3189 is representative of a new class of compounds with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837.
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