Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers

DOI: 10.1016/j.bmcl.2006.09.021

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 6213 - 6218 (2006)

Update date:2022-07-30

Topics:

Authors:

Wu, Shengde

Fluxe, Andrew

Sheffer, Jim

Janusz, John M.

Blass, Benjamin E.

White, Ron

Jackson, Chris

Hedges, Richard

Murawsky, Michael

Fang, Bin

Fadayel, Gina M.

Hare, Michelle

Djandjighian, Laurent

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Article abstract of DOI:10.1016/j.bmcl.2006.09.021

A novel class of tetrazole-derived Kv1.5 blockers is disclosed. In in vitro studies, several compounds had IC₅₀s ranging from 180 to 550 nM. In vivo studies indicated that compounds 2f and 2j increased right atrial ERP about 40% without affecting ventricular ERP.

Full text of DOI:10.1016/j.bmcl.2006.09.021

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