Synthesis of the optically active trans-isomers of diltiazem and their cardiovascular effects and Ca-antagonistic activity

DOI: 10.1248/cpb.40.1476

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1476 - 1480 (1992)

Update date:2022-09-26

Topics:

Authors:

Tanaka Tanaka

Inoue Inoue

Date Date

Okamura Okamura

Aoe Aoe

Takeda Takeda

Kugita Kugita

Murata Murata

Yamaguchi

Kikkawa Kikkawa

Nakajima

Nagao Nagao

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Article abstract of DOI:10.1248/cpb.40.1476

Optically active trans-isomers of diltiazem were synthesized and their cardiovascular effects were evaluated in anesthetized dogs and in isolated guinea pig hearts. Both (+)-2 (2R,3S) and (-)-2 (2S,3R) were much less active than diltiazem (1, 2S,3S) with

Full text of DOI:10.1248/cpb.40.1476

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