SYNTHESIS OF (+)S-α-PERFLUOROETHYL-α-HYDROXYPHENYL ACETIC ACID AND HIGHLY EFFECTIVE AUXILIARIES FOR USE IN ASYMMETRIC INDUCTION

Article abstract of DOI:10.1016/S0040-4039(01)90070-X

Optically pure arene-chromium-tricarbonyl alcohols 2 and 3 (readily available in both enantiomeric forms) which are powerful inducers of chirality in Prelog-type synthesis are presented. 88percent optically pure (+)S-α-perfluoroethyl-α-hydroxyphenylacetic acid is synthesized for the first time in 3 steps and 73percent yield.