Tetrahedron Letters p. 1817 - 1820 (1997)
Update date:2022-09-26
Topics:
De Las Heras, Maria A.
Vaquero, Juan J.
Garcia-Navio, Jose L.
Alvarez-Builla, Julio
A method for the synthesis of 4-oxo and homologous esters is achieved by metalation of alkoxycarbonylalkyl-N-imidazolium-N-methyl amides with 1 equiv of LDA followed by highly chemoselective addition of 1 equiv of a Grignard reagent.
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