Angewandte Chemie - International Edition p. 7786 - 7792 (2006)
Update date:2022-08-02
Topics: Characterization Biological testing Purification Retrosynthetic analysis Final steps Optimization and Scale-Up Synthesis of Fragments Macrocyclization
Nicolaou
Zou, Bin
Dethe, Dattatraya H.
Li, Dong Bo
Chen, David Y.-K.
(Chemical Equation Presented) Beat the bugs: Total syntheses of the thiopeptide antibiotics GE2270A (X-Y = CH2-CH) and GE2270T (X-Y = CH= C) have been accomplished. The modular approach featured a hetero-Diels-Alder dimerization Circled latin capital letter A to construct the trithiazolyl pyridine domain, and highly regioselective macrolactamizations Circled latin capital letter B to furnish the macrocyclic core.
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