Synthesis of N- and side chain protected aspartyl and glutamyl aldehyde derivatives. Reinvestigation of the reduction of Weinreb amides

Article abstract of DOI:10.1016/S0040-4039(97)10813-9

The reduction of Weinreb amides was reinvestigated in order to find conditions that will allow the synthesis of protected aspartyl and glutamyl aldehydes derivatives useful for peptide and pseudopeptide syntheses. We have demonstrated that lithium tris(te