Inhibition of P-glycoprotein-mediated multidrug efflux by aminomethylene and ketomethylene analogs of reversins

DOI: 10.1016/j.bmcl.2006.07.059

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5700 - 5703 (2006)

Update date:2022-07-31

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Authors:

Koubeissi, Ali

Raad, Imad

Ettouati, Laurent

Guilet, David

Dumontet, Charles

Paris, Joelle

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Article abstract of DOI:10.1016/j.bmcl.2006.07.059

Several aminomethylene analogs and a ketomethylene analog of reversins were synthesized in order to evaluate their ability to inhibit P-glycoprotein-mediated drug efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein. These analogs retained

Full text of DOI:10.1016/j.bmcl.2006.07.059

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