
Synthetic Communications p. 301 - 309 (2001)
Update date:2022-08-03
Topics: Coumarins Organic synthesis Nitration Oxidizing agent Mediated
Ganguly
Sukai
De
A new convenient method of nitration of coumarins using cerium(IV) ammonium nitrate (CAN) has been developed. Higher regioselectivity is observed with CAN and hydrogen peroxide in aqueous medium in comparison with CAN in acetic acid for nitration of 7-hydroxycoumarin, 7-hydroxy-4-methylcoumarin and their derivatives.
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Doi:10.1021/jacs.9b07204
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