Chemistry of Heterocyclic Compounds p. 656 - 658 (1984)
Update date:2022-08-03
Topics:
Abramova, N. D.
Skvortsova, G. G.
Trzhtsinskaya, B. V.
1-(α-Alkoxyethyl)- and 1-(α-phenoxyethyl)benzimidazole-2-thiones were obtained in the reaction of 1-vinylbenzimidazole-2-thione with alcohols and phenol in the presence of gaseous hydrogen chloride.It was established that partial hydrolysis of the 1-(α-alkoxyethyl)benzimidazole-2-thiones to benzimidazole-2-thione with subsequent alkylation with excess alcohol at the exocyclic sulfur atom occurs under the conditions of the investigated reaction.A convenient method for the alkylation of thiones was proposed, and a number of 2-alkylthiobenzimidazoles were synthesized.
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