Bioorganic and Medicinal Chemistry Letters p. 1003 - 1008 (1999)
Update date:2022-09-26
Topics:
Edwards, James P.
Higuchi, Robert I.
Winn, David T.
Pooley, Charlotte L. F.
Caferro, Thomas R.
Hamann, Lawrence G.
Zhi, Lin
Marschke, Keith B.
Goldman, Mark E.
Jones, Todd K.
A series of 2H-pyrano[3,2-g]quinolin-2-ones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2H-pyrano[3,2- g]quinolin-2-one, displayed moderate
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