Tetrahedron p. 3765 - 3780 (1998)
Update date:2022-08-05
Topics:
Kretzschmar, Gerhard
A series of low molecular weight sialyl-Lewis(X) analogs based on either rigid or flexible replacements for the carbohydrates were designed as orally available anti-inflammatory drugs, synthesized and tested in cell-based adhesion assays. The flexible glycomimetic 7a lacking any glycoside or peptide linkage was prepared in 4 steps and 41% overall yield from methyl 3,5-dihydroxybenzoate and the fucose derivative 18 and exhibited about equal binding affinity to E- and P-selectin compared to the parent tetrasaccharide.
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Doi:10.1021/ol402800a
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(2007)Doi:10.1002/adsc.200606040
(2006)Doi:10.1016/j.bmcl.2006.12.096
(2007)Doi:10.1016/S0040-4020(01)99184-7
(1963)Doi:10.1002/chem.200700125
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