Synthesis of Ethyl (2RS,3SR)-1-Tosyl-3-vinylazetidine-2-carboxylate and Ethyl (2RS,E)-3-Ethylidene-1-tosylazetidine-2-carboxylate (=rac-Ethyl N-Tosylpolyoximate)

Article abstract of DOI:10.1002/hlca.19880710513

The synthesis of 3-ethylideneazetidine-2-carboxylic acid (=polyoximic acid; 3) is approached in two different ways leading to potential precursors of 3.The first way involved a ring closure to a vinyl-substituted azetidine.Thus, Ireland-Claiser rearrangem