Reaction of 2,2-Difluorovinyl Ketones with Heteroatom Nucleophiles: A General One-Pot Synthesis of α-Oxoketene Acetals

DOI: 10.1016/S0040-4020(01)85658-1

Source and publish data:

Tetrahedron p. 11637 - 11646 (1994)

Update date:2022-08-06

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Authors:

Ichikawa, Junji

Kobayashi, Masakuni

Yokota, Naoyuki

Noda, Yasuharu

Minami, Toru

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Article abstract of DOI:10.1016/S0040-4020(01)85658-1

2,2-Difluorovinyl ketones readily react with heteroatom nucleophiles such as thiols, alcohols, and amines to undergo stepwise replacement of the two fluorine atoms via addition-elimination process.The reaction affords α-oxoketene acetals including S,S-, N

Full text of DOI:10.1016/S0040-4020(01)85658-1

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