A novel synthesis of highly substituted perhydropyrrolizines, perhydroindolizines, and pyrrolidines: Inhibition of the peptidyl-prolyl cis/trans isomerase (PPIase) Pin1

DOI: 10.1002/hlca.200790028

Source and publish data:

Helvetica Chimica Acta p. 217 - 259 (2007)

Update date:2022-08-04

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Authors:

Siegrist, Romain

Zuercher, Martina

Baumgartner, Corinne

Seiler, Paul

Diederich, Francois

Daum, Sebastian

Fischer, Gunter

Klein, Christian

Dangl, Markus

Schwaiger, Manfred

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Article abstract of DOI:10.1002/hlca.200790028

In this paper, we describe the synthesis and biological evaluation of highly substituted perhydropyrrolizines that inhibit the peptidyl-prolyl cis/trans isomerase (PPIase) Pin1, an oncogenic target. The enzyme selectively catalyzes the cis/trans isomeriza

Full text of DOI:10.1002/hlca.200790028

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