Journal of Heterocyclic Chemistry p. 905 - 910 (1999)
Update date:2022-08-05
Topics:
Chung, Hyun-A
Kweon, Deok-Heon
Kang, Young-Jin
Park, Jung-won
Yoon, Yong-Jin
Direct functionalization of 4,5-dichloropyridazin-6-one with some nucleophiles in seven solvents gave regioselectively 5-halo- 4-substituted-pyridazin-6-ones as main product. Reaction of 4,5- dichloropyridazin-6-one with 2-mercaptopyrimidine (2 equivalents) also afforded 4,5-di(pyrimidin-2-ylsulfanyl)pyridazin-6-one as the main product.
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