Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit

DOI: 10.1016/j.bmcl.2007.01.026

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2005 - 2012 (2007)

Update date:2022-08-05

Topics:

Authors:

Backes, Bradley J.

Longenecker, Kenton

Hamilton, Gregory L.

Stewart, Kent

Lai, Chunqiu

Kopecka, Hana

von Geldern, Thomas W.

Madar, David J.

Pei, Zhonghua

Lubben, Thomas H.

Zinker, Bradley A.

Tian, Zhenping

Ballaron, Stephen J.

Stashko, Michael A.

Mika, Amanda K.

Beno, David W.A.

Kempf-Grote, Anita J.

Black-Schaefer, Candace

Sham, Hing L.

Trevillyan, James M.

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Article abstract of DOI:10.1016/j.bmcl.2007.01.026

A novel series of pyrrolidine-constrained phenethylamines were developed as dipeptidyl peptidase IV (DPP4) inhibitors for the treatment of type 2 diabetes. The cyclohexene ring of lead-like screening hit 5 was replaced with a pyrrolidine to enable paralle

Full text of DOI:10.1016/j.bmcl.2007.01.026

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