Journal of Medicinal Chemistry p. 248 - 252 (1985)
Update date:2022-08-04
Topics:
Colbry, Norman L.
Elslager, Edward F.
Werbel, Leslie M.
The synthesis and antimalarial activity of a series of 2,4,6-triaminopyrido<3,2-d>pyrimidines (4) is described.Several 6-substituted benzylmethylamino analogues were more active against trophozoite induced Plasmodium berghei in mice than the corresponding quinazoline analogues.These agents, however, are cross-resistant to other antifolate compounds and are thus of limited potential as human agents.
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