Journal of Medicinal Chemistry p. 248 - 252 (1985)
Update date:2022-08-04
Topics:
Colbry, Norman L.
Elslager, Edward F.
Werbel, Leslie M.
The synthesis and antimalarial activity of a series of 2,4,6-triaminopyrido<3,2-d>pyrimidines (4) is described.Several 6-substituted benzylmethylamino analogues were more active against trophozoite induced Plasmodium berghei in mice than the corresponding quinazoline analogues.These agents, however, are cross-resistant to other antifolate compounds and are thus of limited potential as human agents.
View MoreContact:
Address:
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Xinjiang Zhongtai Chemical Co., Ltd.
Contact:+86-991-8788172
Address:NO.78 XISHAN RD.URUMQI，CHINA
RongCheng Tianyu Technology Co.,Ltd.
Contact:86-631-7519595
Address:220Ping Donghai Road RongChengCity,ShangDong Province China
Shanghai PotentPharm Science and Technology Co.,Ltd
Contact:86-021-51969655
Address:Unit B, Building 18, No.300, Chuantu Rd,Pudong District, Shanghai 201202, China
Doi:10.1016/j.bmcl.2007.01.083
(2007)Doi:10.1016/j.ica.2006.10.043
(2007)Doi:10.1021/jo01018a026
(1965)Doi:10.1021/ja01258a053
(1942)Doi:10.1021/jo030378q
(2004)Doi:10.1016/j.bmc.2007.02.049
(2007)
