Studies toward the total synthesis of gambieric acids A and C: Convergent assembly of the nonacyclic polyether skeleton

Article abstract of DOI:10.1002/anie.200604625

(Chemical Equation Presented) A solid approach to ethereal rings: Key features of a convergent synthesis of the nonacyclic polyether skeleton of gambieric acids A and C include the connection of the BCD and GHIJ ring systems by esterification, the construction of the E ring in the form of a lactone, a stereoselective allylation to establish the C26 stereocenter, and the formation of the F ring by ring-closing metathesis (see scheme; Bn = benzyl, NAP = 2-naphthylmethyl).