Chemical and Pharmaceutical Bulletin p. 2219 - 2224 (1994)
Update date:2022-08-02
Topics:
Oishi
Iwamoto
Okada
Suzuki
Tanji
Miyashita
Higashino
1-Chlorophthalazine (1) reacts with a 2-fold molar excess of ynamines 2a, b to give penta-substituted pyridine derivatives 3a,b by nitrogen-nitrogen bond cleavage of the pyridazine ring with release of hydrogen chloride. Similarly, other fused pyridazines having a chloro substituent α to nitrogen in the pyridazine ring, i.e., pyrido[3,4-d]- (10a), pyrido[2,3-d]- (10b), thiazolo[4,5-d]- (10c, d), furo[2,3-d]- (10e) and pyrrolo[2,3-d]- (10f, g) pyrfdazine derivatives, gave the corresponding penta-suhstituted pyridines 11a-11k.
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