Bioorganic and Medicinal Chemistry p. 3225 - 3234 (2007)
Update date:2022-08-03
Topics: High-performance liquid chromatography (HPLC) Phenyl ring
Roman, Gheorghe
Riley, John G.
Vlahakis, Jason Z.
Kinobe, Robert T.
Brien, James F.
Nakatsu, Kanji
Szarek, Walter A.
A series of 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes comprising imidazole-ketones, imidazole-dioxolanes, and imidazole-alcohols substituted with halogens in the phenyl ring were synthesized and evaluated as novel inhibitors of heme oxygenase which are structurally distinct from metalloporphyrins. The entire library of compounds was found to be highly active, with the bromine- and iodine-substituted derivatives being the most potent. The imidazole-dioxolanes were all selective for the HO-1 isozyme (inducible) and exhibited substantially lower activity toward the HO-2 isozyme (constitutive). The corresponding imidazole-ketones and imidazole-alcohols showed selectivity toward HO-1 to a lesser degree than the similarly substituted imidazole-dioxolanes.
View MoreContact:86-574-26865651
Address:529 YuanBaoShan Road, Beilun District
Anhui Sunsing Chemicals Co.,Ltd
website:http://www.sunsingchem.com
Contact:0086-566-2023179
Address:Jin An industry park, Chizhou economic technical development zone, Anhui
Liao Cheng All Win Chemicals Co.,LTD
Contact:86+0635-2991582
Address:Room 402,Unit 1,No.27 building.Zhong tong shi dai haoyuan,liaocheng city,Shan dong Province.China
Contact:+33-5-34012600
Address:28 ZA des Pignès
website:http://www.uvchemkeys.com
Contact:0086-021-58785816
Address:RM2607 Building No.1 Guosheng, Lane 388, Zhongjiang Road, Putuo District, Shanghai 200062 China
Doi:10.1039/a806621c
(1999)Doi:10.1016/S0040-4039(01)81539-2
(1984)Doi:10.1080/14756366.2016.1268608
(2017)Doi:10.1002/chem.201905651
(2019)Doi:10.1021/jm070111+
(2007)Doi:10.1016/j.ica.2007.01.002
(2007)