
Tetrahedron Letters p. 4841 - 4844 (1984)
Update date:2022-08-04
Topics:
Garcia, Jordi
Urpi, Felix
Villarasa, Jaume
Equimolar amounts of carboxylic acids, aryl or alkyl azides, and Ph3P in refluxing benzene (hexane, toluene) afford amides in good yields.Insolubility of zwitterions Ph3P(+)-NH(CH2)nCOO(-), arising from ω-azido acids and Ph3P, limits the utilization of the method for lactame formation.
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