Organic and Biomolecular Chemistry p. 2719 - 2727 (2010)
Update date:2022-08-04
Topics:
Verdoes, Martijn
Willems, Lianne I.
Van Der Linden, Wouter A.
Duivenvoorden, Boudewijn A.
Van Der Marel, Gijsbert A.
Florea, Bogdan I.
Kisselev, Alexei F.
Overkleeft, Herman S.
Mammals express seven different catalytically active proteasome subunits. In order to determine the roles of the different proteolytically active subunits in antigen presentation and other cellular processes, highly specific inhibitors and activity-based probes that selectively target specific active sites are needed. In this work we present the development of fluorescent activity-based probes that selectively target the β1 and β5 sites of the constitutive proteasome.
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