European Journal of Medicinal Chemistry p. 3765 - 3770 (2009)
Update date:2022-08-03
Topics:
Meppen, Malte
Pacini, Barbara
Bazzo, Renzo
Koch, Uwe
Leone, Joseph F.
Koeplinger, Kenneth A.
Rowley, Michael
Altamura, Sergio
Di Marco, Annalise
Fiore, Fabrizio
Giuliano, Claudio
Gonzalez-Paz, Odalys
Laufer, Ralph
Pucci, Vincenzo
Narjes, Frank
Gardelli, Cristina
The currently approved treatment for hepatitis C virus infections is a combination of Ribavirin and pegylated Interferon. It leads to a sustained virologic response in approximately only half of the patients treated. For this reason there is an urgent need of new therapeutic agents. 2′-C-Methylcytidine is the first nucleoside inhibitor of the HCV NS5B polymerase that was efficacious in reducing the viral load in patients infected with HCV. The application of a monophosphate prodrug approach based on unprecedented cyclic phosphoramidates is reported. Our SAR studies led to compounds that are efficiently converted to the active triphosphate in human hepatocytes.
View MoreJurong Huaheng Natural Biological Products Factory
website:http://www.risebiochem.com
Contact:+86-13921007726
Address:Chuncheng town,Jurong city,Jiangsu province,China
Lonzeal Pharmaceuticals Co., Ltd.
website:http://www.lonzeal.com
Contact:+86-13381011962
Address:RM 801, Yue MOMA, No. 26 Anningzhuang Rd. Haidian District, Beijing, China
Shandong Dayi Chemical Co., Ltd.
website:http://www.dayi.com.cn
Contact:+86- 535-7388728. 15306386031
Address:No 1 Danya west road, Laiyang City, Shandong province
Shanghai Potomer International Trade CO., LTD
Contact:+86-21-61397128
Address:Room 304,No.505 ,Caoyang Road.Shanghai,China
Jiangyin Tenghua Import&Export Co.,Ltd.
Contact:+86-510-86263875
Address:Room 402-B,9 Yanling Road, Jiangyin,Jiangsu, China
Doi:10.1007/s00706-012-0851-0
(2013)Doi:10.1039/c2cc35309a
(2012)Doi:10.1021/acs.jmedchem.0c00395
(2020)Doi:10.1016/j.tetlet.2016.06.029
(2016)Doi:10.1007/s11426-013-4925-6
(2013)Doi:10.1021/la303061r
(2012)