Total synthesis of (-)-archazolid B

DOI: 10.1021/ja0733033

Source and publish data:

Journal of the American Chemical Society p. 8960 - 8961 (2007)

Update date:2022-08-03

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Authors:

Roethle, Paul A.

Chen, Ingrid T.

Trauner, Dirk

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Article abstract of DOI:10.1021/ja0733033

A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the ar

Full text of DOI:10.1021/ja0733033

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