Synthesis and biological activity of azido analogues of 5,6-dimethylxanthenone-4-acetic acid for use in photoaffinity labeling

DOI: 10.1021/jm0702175

Source and publish data:

Journal of Medicinal Chemistry p. 3757 - 3764 (2007)

Update date:2022-07-30

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Authors:

Palmer, Brian D.

Henare, Kimiora

Woon, See-Tarn

Sutherland, Rachel

Reddy, Charu

Wang, Liang-Chuan S.

Kieda, Claudine

Ching, Lai-Ming

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Article abstract of DOI:10.1021/jm0702175

5,6-Dimethylxanthenone-4-acetic acid (1) is scheduled for phase III clinical trials as a vascular disrupting agent. However, its biochemical receptor(s) have yet to be identified. In this report, the synthesis of azido analogues of 1 that could be used fo

Full text of DOI:10.1021/jm0702175

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