TOTAL SYNTHESIS OF (+/-)-PANICULIDE-A

Article abstract of DOI:10.1016/S0040-4020(01)87731-0

An efficient synthesis of the paniculide A precursor 4 has been achieved beginning with 3-methylglutaric anhydride, and utilizing as the key step an intramolecular Diels-Alder reaction of an acetylenic oxazole to give a 2-methoxyfuran.Acid hydrolysis then provided the requisite butenolide ring characteristic of the paniculides.