Bioorganic and Medicinal Chemistry Letters p. 4878 - 4881 (2007)
Update date:2022-07-31
Topics:
Minutolo
Cascio
Carboni
Bisogno
Prota
Bertini
Digiacomo
Bifulco
Di Marzo
Macchia
Biphenylic ester derivatives, designed by using a 'soft-drug' approach, proved to possess good binding properties toward cannabinoid CB1 and CB2 receptors and, at the same time, their metabolically labile ester portion would promote a rapid systemic inactivation. This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents.
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