YNAZIRIDINES. METHODS OF SYNTHESIS OF A NEW TYPE OF YNAMINES

Article abstract of DOI:10.1007/BF00505713

Ways of synthesizing ynaziridines by succesive halogenation and dehydrohalogenation of enaziridino esters, the reaction of potassium aziridinide with bromophenylacetylene, the reaction of 1H-aziridines with the methyl ester of bromopropionic acid was studied.The different direction of the reaction of aziridines with bromomethylpropiolate as a function of the nature of the solvent was demonstrated.In methanol the addition of aziridine to the triple bond proceeds stereospecifically with the formation of the E-isomer.When this reaction was conducted in ether, ynaziridines were obtained for the first time.An effective method of synthesis of ynaminoesters was developed.