Electrostatic effects in acylation of hemoglobin by aspirins

DOI: 10.1002/jps.2600731255

Source and publish data:

Journal of Pharmaceutical Sciences p. 1851 - 1853 (1984)

Update date:2022-08-05

Topics:

Authors:

Massil Massil

Shi Shi

Klotz Klotz

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Article abstract of DOI:10.1002/jps.2600731255

Carboxylate substituents added to the salicylate ring increase the effectiveness of a variety of aspirins and diaspirins in acylating hemoglobin. Even more effective are a series of monoesters of dicarboxylate derivatives. Bis(5-carbomethoxysalicyl)fumarate and -succinate at 5 mM concentrations modify ~100% of the hemoglobin in solution and should alter the aggregation behavior of sickle hemoglobin.

Full text of DOI:10.1002/jps.2600731255

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