Journal of Pharmaceutical Sciences p. 1851 - 1853 (1984)
Update date:2022-08-05
Topics:
Massil
Shi
Klotz
Carboxylate substituents added to the salicylate ring increase the effectiveness of a variety of aspirins and diaspirins in acylating hemoglobin. Even more effective are a series of monoesters of dicarboxylate derivatives. Bis(5-carbomethoxysalicyl)fumarate and -succinate at 5 mM concentrations modify ~100% of the hemoglobin in solution and should alter the aggregation behavior of sickle hemoglobin.
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