THE METHYLENATION OF ENOLIZABLE KETONES AND ESTERS USING ORGANOTITANIUM CHEMISTRY

Article abstract of DOI:10.1016/S0040-4039(01)81672-5

The titanium methylidene fragment, Cp2Ti=CH2, resulting from Tebbe's reagent, Cp2TiCH2*AlMe2Cl or the β,β-disubstituted metallacycle, Cp2TiCH2C(Me)(n-Pr)CH2, methylenates enolizable acidic ketones and converts α,α-disubstituted ketones into titanium enolates.The reagent reacts selectively with ketones over esters.