Efficient Catalytic Asymmetric Alkylations. 3. A Kinetic and Mechanistic Study of the Enantioselective Phase-Transfer Methylation of 6,7-Dichloro-5-methoxy-2-phenyl-1-indanone

Article abstract of DOI:10.1021/jo00230a017

The phase-transfer methylation of 6,7-dichloro-5-methoxy-2-phenyl-1-indanone by MeCl in 50percent NaOH/toluene using substituted N-benzylcinchoninium halides has provided the methylated indanone 2 in ee's up to 94percent.The effects of solvent, alkylating