Efficient Catalytic Asymmetric Alkylations. 3. A Kinetic and Mechanistic Study of the Enantioselective Phase-Transfer Methylation of 6,7-Dichloro-5-methoxy-2-phenyl-1-indanone

DOI: 10.1021/jo00230a017

Source and publish data:

Journal of Organic Chemistry p. 4745 - 4752 (1987)

Update date:2022-08-04

Topics:

Authors:

Hughes, D. L.

Dolling, U.-H.

Ryan, K. M.

Schoenewaldt, E. F.

Grabowski, E. J. J.

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Article abstract of DOI:10.1021/jo00230a017

The phase-transfer methylation of 6,7-dichloro-5-methoxy-2-phenyl-1-indanone by MeCl in 50percent NaOH/toluene using substituted N-benzylcinchoninium halides has provided the methylated indanone 2 in ee's up to 94percent.The effects of solvent, alkylating

Full text of DOI:10.1021/jo00230a017

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