[(Aminomethyl)aryloxy]acetic acid esters. A new class of high-ceiling diuretics. 4. Substituted 6,7-dichloro-2,3-dihydrobenzofurans derived by ring annelation.

DOI: 10.1021/jm50001a009

Source and publish data:

Journal of medicinal chemistry p. 589 - 594 (1985)

Update date:2022-09-26

Topics:

Authors:

Lee Lee

Parks Parks

Bunnell Bunnell

Plattner

Field Field

Giebisch

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Article abstract of DOI:10.1021/jm50001a009

Ring annelation of the [(aminomethyl)aryloxy]acetic acids produced a series of substituted 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acids. Pharmacologic evaluation of these compounds in rats and dogs indicated that several congeners are extremely p

Full text of DOI:10.1021/jm50001a009

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