A stereoselective access to dihydroxylated pyrrolidines by reductive ring contraction of 1,2-oxazines

DOI: 10.1055/s-2007-983802

Source and publish data:

Synthesis p. 2681 - 2689 (2007)

Update date:2022-08-04

Topics:

Authors:

Reissig, Hans-Ulrich

Homann, Kai

Hiller, Florian

Zimmer, Reinhold

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Article abstract of DOI:10.1055/s-2007-983802

Protected dihydroxylated 1,2-oxazine derivatives such as rac-4 were converted into tetrahydro-1,2-oxazines rac-7 by employing BH₃· THF for the stereoselective reduction of the C=N bond. Compound 7a underwent a reductive ring contraction on hydr

Full text of DOI:10.1055/s-2007-983802

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