Tetrahedron Letters p. 1121 - 1124 (1980)
Update date:2022-08-04
Topics:
Marlier, John F.
Benkovic, Stephen J.
A method is described for the chemical synthesis of the title compounds (Ap(S)A) via addition of elemental sulfur to a phosphite triester intermediate. Separation of the diastereomers of phosphorus could be accomplished on silica gel after removal of the terminal 5′-hydroxyl protecting group or on DEAE cellulose after complete deblocking. The triester to terminal 5′-hydroxyl. The overall yield of the synthesis (one coupling and four deblocking steps) is 30%.
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