Tetrahedron p. 1821 - 1830 (1993)
Update date:2022-09-26
Topics:
Enders, Dieter
Papadopoulos, Kyriakos
Herdtweck, Eberhardt
A simple and efficient enantioselective synthesis of 2-substituted 4-oxosulfones 5 in 40 - 71 percent overall chemical yield and enantiomeric excesses of 86 -> 97 percent is described.The key is an asymmetric Michael-addition of lithiated methylketone-SAMP-/RAMP-hydrazones 3 to α,β-unsaturated phenylsulfones 2.The absolute configuration is determined by X-ray structure analysis of a crystalline hydrazone Michael adduct (4k) and through chemical correlation by polarimetry.
View Morewebsite:http://www.easchem.com
Contact:+86-731-89722861 89722891
Address:2/F-4/Bld Colorful Palace, No.605 Changsha Ave, Yuhua Area Changsha Hunan China.
Beijing Cooperate Pharmaceutical Co.,Ltd
website:http://www.cooperate-pharm.com/
Contact:86-01060279497
Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base
Shanghai doly chemical Co.,Ltd
Contact:+86-21-34716221
Address:No.328,WuHe Roard,MinHang,ShangHai China
NANCHANG QINZHI SCI&TEC.CO.,LTD(expird)
Contact:+86-13687004106
Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China
Hebei Think-Do Environment Co., Ltd
website:http://www.thinkdo-environment.com
Contact:0311-86510809-
Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
Doi:10.1016/j.bmcl.2014.11.050
(2015)Doi:10.1002/anie.200702036
(2007)Doi:10.1021/jo701665j
(2007)Doi:10.1021/om700688p
(2007)Doi:10.1016/S0040-4039(00)89172-8
(1985)Doi:10.1021/jm070620b
(2007)
