Tetrahedron p. 4237 - 4244 (1984)
Update date:2022-07-29
Topics: Preparation Experimental conditions Base-catalyzed cleavage reaction Protected peptides
Whitney, Donald B.
Tam, James P.
Merrifield, R. B.
A new base-catalyzed elimination reaction employing the hindered, non-nucleophilic bases tetramethylguanidine or 1,8-diazabicyclo-<5.4.0.>-undec-7-ene has been developed for the removal of protected peptides from a 2-<4-(hydroxymethyl)phenyl-acetoxy>propi
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