Journal of Organic Chemistry p. 1464 - 1467 (1985)
Update date:2022-08-04
Topics:
Kuehne, Martin E.
Reider, Paul J.
A synthesis of ibogamine was developed by elaboration of 5-carbomethoxy-3-ethylcyclohexene.The latter was obtained as a 1:1 epimeric mixture from condensation of diethyl (2-ethyl-3-oxopropyl)malonate with triphenylvinylphosphonium bromide, followed by hydrolysis, decarboxylation, and esterification.
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