Ellipticine Derivatives with an Affinity to the Estrogen Receptor, an Approach to Develop Intercalating Drugs with a Specific Effect on the Hormone-Dependent Breast Cancer

DOI: 10.1021/jm00383a010

Source and publish data:

Journal of Medicinal Chemistry p. 752 - 761 (1985)

Update date:2022-09-26

Topics:

Authors:

Delbarre, Alain

Oberlin, Robert

Roques, Bernard P.

Borgna, Jean-Louis

Rochefort, Henri

et al. et al.

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Article abstract of DOI:10.1021/jm00383a010

In order to obtain breast tumor directed agents, we have prepared mixed compounds using estradiol or (E)-clomiphene as specific vectors for the breast tissue and a DNA intercalator from the ellipticine series as cytotoxic agent.Among the newly synthesized

Full text of DOI:10.1021/jm00383a010

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