Ellipticine Derivatives with an Affinity to the Estrogen Receptor, an Approach to Develop Intercalating Drugs with a Specific Effect on the Hormone-Dependent Breast Cancer

Article abstract of DOI:10.1021/jm00383a010

In order to obtain breast tumor directed agents, we have prepared mixed compounds using estradiol or (E)-clomiphene as specific vectors for the breast tissue and a DNA intercalator from the ellipticine series as cytotoxic agent.Among the newly synthesized