Journal of Medicinal Chemistry p. 831 - 833 (1985)
Update date:2022-09-26
Topics:
Weintraub
Blohm
Laughlin
20-(Hydroxymethyl)-4-methyl-4-aza-2-oxa-5α-pregnan-3-one and the corresponding 3-thione were synthesized with use of 20-(hydroxymethyl)-4- methyl-4-aza-5α-pregnan-3-one as the starting material. The compounds were tested in vitro for inhibition of testosterone 5α-reductase and found to be weak inhibitors with K(i)'s in the 10-7 range.
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Doi:10.1016/0008-6215(85)85145-4
(1985)Doi:10.1002/ejoc.201900478
(2019)Doi:10.1007/BF00779077
(1977)Doi:10.1021/ja01630a020
(1954)Doi:10.1021/ja00865a027
(1962)Doi:10.1021/ja01132a042
(1952)
